Ahuja, S.; Lazar, I.M., Anti-Inflammatory Cytokine Stimulation of HMC3 Cells: Proteome Dataset, Data in Brief2023, 49, Article 109433. (https://doi.org/10.1016/j.dib.2023.109433 )
Lazar, I.M., Karcini, A., Haueis, J., Mapping the Cell-Membrane Proteome to the Cancer Hallmarks, PLoS ONE2022, 17(8): e02723842022. (doi.org/10.1371/journal.pone.0272384)
Karcini, A.; Lazar, I.M., The SKBR3 Cell-Membrane Proteome: Role in Aberrant Cancer Cell Proliferation and Resource for Precision Medicine Applications, Sci. Rep. 2022, 12, Article number: 10847. (doi.org/10.1038/s41598-022-14418-0)
Ahuja, S.; Lazar, I.M., Systems-Level Proteomics Evaluation of Microglia Response to Tumor-Supportive Anti-inflammatory Cytokines, Front. Immunol.2021, 12, Article 646043. (https://doi.org/10.3389/fimmu.2021.646043)
Lazar, I.M.; Gulakowski, N.S.; Lazar, A.C., Protein and Proteome Measurements with Microfluidic Chips, Anal. Chem.2020, 92, 1, 169-182. (doi.org/10.1021/acs.analchem.9b04711)
Aguilera Flores, M.; Lazar, I.M., XMAn v2 – A Database of Homo sapiens Mutated Peptides, Bioinformatics2020, 36(4), 1311-1313. (doi: 10.1093/bioinformatics/btz693)
Lazar, I.M.; Karcini, A.; Ahuja, S.; Estrada-Palma, C., Proteogenomic Analysis of Protein Sequence Alterations in Cancer Cells, Sci. Rep.2019, 9, Article number10381 (13 pages). (doi: 10.1038/s41598-019-46897-z)
Xiong, W.; Tang, T.-X.; Littleton, E.; Karcini, A.; Lazar, I.M.; Capelluto, D.G.S., Preferential phosphatidylinositol 5-phosphate binding contributes to a destabilization of the VHS domain structure of Tom1, Sci. Rep. 2019, 9, Article number: 10868 (12 pages). (doi: 10.1038/s41598-019-47386-z).
Lazar, I.M.; Deng, J.; Stremler, M.A.; Ahuja, S., Microfluidic Reactors for Advancing the MS Analysis of Fast Biological Responses, Microsystems & Nanoengineering2019, 5, 7. (doi.org/10.1038/s41378-019-0048-3)
Lazar, I.M., Achieving Stable Electrospray Ionization Mass Spectrometry Detection from Microfluidic Chips, chapter in Microfluidic Electrophoresis, book in the series of Methods in Molecular Biology, Debashis Dutta, Ed., Humana Press, New York, NY, 2019, vol. 1906, 225-237. (doi: 10.1007/978-1-4939-8964-5_15)
Deng, J.; Ikenishi, F.; Smith, N.; Lazar I.M., Streamlined Microfluidic Analysis of Phosphopeptides Using Stable Isotope-Labeled Synthetic Peptides and MRM-MS Detection, Electrophoresis2018, 39(24), 3171-3184. (doi: 10.1002/elps.201800133)
Deng, J.; Julian, M.H.; Lazar I.M., Partial Enzymatic Reactions: A Missed Opportunity in Proteomics Research. Rapid Commun. Mass Spectrom. 2018, 32, 2065-2073. (doi.org/10.1002/rcm.8283)
Lazar, I.M.; Hoeschele, I.; De Morais, J.A.; Tenga, M.J., Cell Cycle Model System for Advancing Cancer Biomarker Research, Sci. Rep. 2017, 7, 17989 (12 p.). (doi:10.1038/s41598-017-17845-6)
Lazar, I.M., Bioinformatics Resources for Interpreting Mass Spectrometry Proteomics Data, chapter in Proteomics for Drug Discovery, book in the series of Methods in Molecular Biology, Iulia M. Lazar, Maria Kontoyianny and Alexandru C. Lazar, Eds., Humana Press, New York, NY, 2017, vol. 1647, 267-295. (doi:10.1007/978-1-4939-7201-2_19)
Cortes, D.F.; Tang, T.-X.; Capelluto, D.; Lazar, I.M., Nanoflow Valve for the Removal of Trapped Air in Microfluidic Devices, Sens. Actuators B, 2017, 243, 650–657. (doi:10.1016/j.snb.2016.12.034)
Tang, T.-X.; Jo, A.; Deng, J.; Jeffrey F. Ellena, F.J.; Lazar, I.M.; Davis, R.M.; Capelluto, D.G.S., Structural, thermodynamic, and phosphatidylinositol 3-phosphate binding properties of Phafin2, Protein Science, 2017, 26(4), 814-823. (doi: 10.1002/pro.3128)
Deng, J.; Lazar I.M., Proteolytic Digestion and TiO2 Phosphopeptide Enrichment Microreactor for Fast MS Identification of Proteins, J. Am. Soc. Mass Spectrom. 2016, 27(4), 686-698. (doi:10.1007/s13361-015-1332-6)
Lazar I.M.; Deng, J.; Smith, N., Fast Enzymatic Processing of Proteins for MS Detection with a Flow-through Microreactor, J. Vis. Exp.2016, 1-7; e53564. (doi: 10.3791/53564)
Lazar, I.M., Microfluidic Devices in Diagnostics: What Does the Future Hold, Future Science2015, 7(20), 2677-2680.
Lazar, I.M., Deng, J.; Ikenishi, F.; Lazar, A.C., Exploring the Glycoproteomics Landscape with Advanced MS Technologies, Electrophoresis2015, 36(1), 225-237. (doi:10.1002/elps.201400400)
Yang, X.; Lazar, I.M., XMAn: A Homo sapiens Mutated-Peptide Database for MS Analysis of Cancerous Cell States, J. Proteome Res. 2014, 13(12), 5486-5495. (doi:10.1021/pr5004467)
Tenga, M.J.; Lazar, I.M., Proteomic Study Reveals a Functional Network of Cancer Markers in the G1-Stage of the Breast Cancer Cell Cycle, BMC Cancer2014, 14, 710 (17 pages). (doi: 10.1186/1471-2407-14-710)
Lee, W.L.; Lazar, I.M., Endogenous Protein “Barcode” for Data Validation and Normalization in Quantitative MS Analysis, Anal. Chem. 2014, 86(13), 6379-6386. (doi: 10.1021/ac500855q)
Lazar, I.M., Invited supplement to A Proteomic Snapshot of Breast Cancer Cell Cycle: The G1/S Transition Point, Biomedical Frontiers2014, April 24.
Lazar I.M., LC-MS/Proteomics: A Platform for the Identification and Selection of Drug Targets, Chimica Oggi2014, 32/2, 18-22.
Lazar, I.M.; Kabulski, J.L.,Microfluidic LC Device with Orthogonal Sample Extraction for On-Chip MALDI-MS Detection, LabChip2013, 13(11), 2055-2065. (doi: 10.1039/C3LC50190F )
Tenga, M.J.; Lazar, I.M., Proteomic Snapshot of Breast Cancer Cell Cycle: G1/S Transition Point, Proteomics2013, 13(1), 48-60 (Epub, Nov. 14, 2012). (doi.org/10.1002/pmic.201200188)
Lazar, I.M., Lee, W.L., Lazar, A.C., Glycoproteomics on the Rise: Established Methods, Advanced Techniques, Sophisticated Biological Applications, Electrophoresis2013, 34, 113-125 (Epub, Oct. 19, 2012). (doi.org/10.1002/elps.201200445)
Mao, X.; Lazar, I.M., Applications of Microfluidic Devices with Mass Spectrometry Detection in Proteomics, Chapter in Sample Preparation in Biological Mass Spectrometry, Alexander Ivanov and Alexander Lazarev, Eds., Springer, 2011, 1051-1074. (book chapter) (doi.org/10.1007/978-94-007-0828-0_49)
Tenga, M.J.; Lazar, I.M., Impact of Peptide Modifications on iTRAQ Quantitation Accuracy, Anal. Chem., 2011, 83(3), 701-707. (doi: 10.1021/ac100775s)
Lazar, I.M.; Lazar, A.C.; Bermudez, D.C.; Kabulski, J.L., Recent Advances in the Mass Spectrometric Analysis of Glycoproteins: Theoretical Considerations, Electrophoresis2011, 32, 3-13. (doi.org/10.1002/elps.201000393)
Bermudez, D.C.; Kabulski, J.L.; Lazar, A.C.; Lazar, I.M., Recent Advances in the Mass Spectrometric Analysis of Glycoproteins: Capillary and Microfluidic Workflows, Electrophoresis2011, 32, 14-29. (doi.org/10.1002/elps.201000394)
Armenta, J.M.; Perez, M.J.; Yang, X.; Shapiro, D.; Reed, D.; Tuli, L.; Finkielstein, C.V.; Lazar, I.M., Fast Proteomic Protocol for Biomarker Fingerprinting in Cancerous Cells, J. Chromatogr. A 2010, 1217, 2862-2870. (doi.org/10.1016/j.chroma.2010.02.065)
Lazar, I.M., Microfluidic Bioanalytical Platforms with Mass Spectrometry Detection for Biomarker Discovery and Screening, Chapter in Miniaturization and Mass Spectrometry, Royal Society of Chemistry, Séverine Le Gac and Albert van den Berg Eds., Royal Society of Chemistry, 1st Edition, Jan. 2009, 151-172. (book chapter)
Armenta, J.M.; Hoeschele, I.; Lazar, I.M., Differential Protein Expression Analysis Using Stable Isotope Labeling and PQD Linear Ion Trap MS Technology, J. Am. Soc. Mass Spectrom.2009, 20, 1287-1302. (doi.org/10.1016/j.jasms.2009.02.029)
Yang, X.; Lazar, I.M., MRM Screening and Biomarker Discovery: A Library of Human Cancer-Specific Peptides, BMC Cancer 2009, 9(1), 96 (11 pages). (doi.org/10.1186/1471-2407-9-96)
Armenta, J.M.; Dawoud, A.A.; Lazar, I.M., Microfluidic Chips for Protein Differential Expression Profiling, Electrophoresis2009, 30, 1145-1156. (doi.org/10.1002/elps.200800653)
Lazar, I.M., Recent Advances in Capillary and Microfluidic Platforms with MS Detection for the Analysis of Phosphoproteins, Electrophoresis 2009, 30, 262-275. (doi.org/10.1002/elps.200800427)
Lazar, I.M., Microfluidic Devices with Mass Spectrometry Detection,” Chapter in Handbook of Capillary and Microchip Electrophoresis and Associated Microtechniques, James P. Landers Ed., CRC Press, 3rd Edition, Dec. 13th, 2007, 1459-1506. (book chapter)
Dawoud, A.A.; Sarvaiya, H.A.; Lazar, I.M., Microfluidic Platform with Mass Spectrometry Detection for the Analysis of Phosphoproteins, Electrophoresis2007, 28, 4645-4660. (doi.org/10.1002/elps.200700355)
Lazar, I.M.; Trisiripisal, P.; Sarvaiya, H.A., Microfluidic Liquid Chromatography System for Proteomic Applications and Biomarker Screening, Anal. Chem.2006, 78(15), 5513-5524. (doi: 10.1021/ac060434y)
Sarvaiya, H.A.; Yoon, J.H.; Lazar, I.M., Proteome Profile of the MCF7 Cancer Cell Line: a Mass Spectrometric Evaluation, Rapid Commun. Mass Spectrom. 2006, 20, 3039-3055. (doi.org/10.1002/rcm.2677)
Lazar, I.M.; Grym, J.; Foret, F., Microfabricated Devices: A New Sample Introduction Approach to Mass Spectrometry, Mass Spectrom. Rev. 2006, 25, 573-594. (doi.org/10.1002/mas.20081)
Bissel, P.; Geherin, S.; Igarashi, K.; Gandour, R.D.; Lazar, I.M.; Castagnoli, N. Jr., Mass Spectrometric Studies on 4-Aryl-1-Cyclopropyl-1,2-Dihydropyridinyl Derivatives: an Examination of a Novel Fragmentation Pathway, J. Mass Spectrom. 2006, 41(12), 1643-1653. (doi.org/10.1002/jms.1195)
Lazar, I.M.; Li, L.; Yang, Y.; Karger, B.L., Microfluidic Device for Capillary Electro-Chromatography Mass Spectrometry, Electrophoresis, 2003, 24(21), 3655-3662. (doi.org/10.1002/elps.200305609)
Lazar, I.M.; Karger, B.L., Multiple Open-Channel Electroosmotic Pumping System for Microfluidic Sample Handling, Anal. Chem. 2002, 74(24), 6259-6268. (doi: 10.1021/ac0203950)
Lazar, I.M.; Ramsey, R.S.; Ramsey, J.M., On-Chip Proteolytic Digestion and Analysis Using “Wrong-Way-Round” Electrospray Time-of-Flight Mass Spectrometry, Anal. Chem. 2001, 73(8), 1733-1739. (doi: 10.1021/ac001420+)
Lazar, I.M.; Karger, B.L., Microchip Integrated Analysis System for Electrospray Mass Spectrometric Analysis of Complex Peptide Mixtures, in Micro Total Analysis Systems, J. Michael Ramsey and Albert van der Berg, Eds., Kluwer Academic Publishers, Dordrecht, 2001, p. 219-221.
Lazar, I.M.; Ramsey, R.S.; Jacobson, S.C.; Foote, R.S.; Ramsey, J.M., Novel Microfabricated Device for Electrokinetically Induced Pressure Flow and Electrospray Ionization Mass Spectrometry, J. Chromatogr. A 2000, 892, 195-201. (doi.org/10.1016/S0021-9673(00)00335-6)
Lazar, I.M.; Lee, E.D.; Sin, J.C.H.; Rockwood, A.L.; Onuska, K.D.; Lee, M.L., Electrospray Ionization Time-of-Flight Mass Spectrometric Detection for Fast Liquid Phase Separations, Am. Lab. 2000, 32(3), 110-119.
Lazar, I.M.; Ramsey, R.S.; Ramsey, J.M., Microchip-Nano-Electrospray Device for Rapid On-Chip Digestion and MS Analysis of Hemoglobin Variants, in Micro Total Analysis Systems, J. Michael Ramsey and Albert van der Berg, Eds., Kluwer Academic Publishers, 2000, p. 379-382.
Lazar, I.M.; Naisbitt, G.; Lee, M.L., Capillary Electrophoresis Time-of-Flight Mass Spectrometry of an Opium Extract, Chromatographia1999, 50, 188-194. (doi: 10.1007/BF02490650)
Lazar, I.M.; Lee, M.L., Effect of Electrospray Needle Voltage on Electroosmotic Flow in Capillary Electrophoresis-Mass Spectrometry, J. Am. Soc. Mass Spectrom.1999, 10, 261-264. (doi.org/10.1016/S1044-0305(98)00151-2)
Nelson, C.R.; Li, W.; Lazar, I.M.; Larson, K.C.; Malik, A.; Lee, M.L., Geochemical Significance of n-Alkane Compositional Trait Variations in Coals, Energy and Fuels1998, 12, 277-283. (doi: 10.1021/ef970112k)
Lazar, I.M.; Naisbitt, G.; Lee, M.L., Capillary Electrophoresis Time-of-Flight Mass Spectrometry of Drugs of Abuse, The Analyst1998, 123, 1449-1454. (doi: 10.1039/A708903A)
Lazar, I.M.; Lee, E.D.; Rockwood, A.L.; Lee, M.L., General Considerations for Optimizing a CE-ESI-TOFMS System, J. Chromatogr. A1998, 829, 279-288. (doi: 10.1016/S0021-9673(98)00743-2)
Lee, M.L.; Lazar, I.M., Comparison of Mass Spectrometry Interfacing Techniques for Microcolumn Separations, Biomed. Chromatogr. 1998, 12(3), 141-142.
Li, W.; Lazar, I.M.; Wan, Y. J.; Butala, S.J.; Shen, Y.; Malik, A.; Lee, M.L., Determination of Volatile Hydrocarbons in Coals and Shales Using Supercritical Fluid Extraction and Chromatography, Energy and Fuels1997, 11, 945-950. (doi: 10.1021/ef960176f)
Lazar, I.M.; Lee, E.D.; Rockwood, A.L.; Lee, M.L., Evaluation of an Electrospray Interface for Capillary Electrophoresis Time-of-Flight Mass Spectrometry, J. Chromatogr. A1997, 791, 269-278. (doi.org/10.1016/S0021-9673(97)00811-X)
Lazar, I.M.; Xin, B.; Lee, E.D.; Rockwood, A.L.; Fabbi, J.C.; Lee, H.G.; Lee, M.L., Design of a Time-of-Flight Mass Spectrometer as a Detector for Capillary Electrophoresis, Anal. Chem. 1997, 69, 3205-3211. (doi: 10.1021/ac9700282)
Lazar, I.M.; Lee, E.D.; Lee, M.L., Design and Optimization of a Corona Discharge Ion Source for Supercritical Fluid Chromatography TOF Mass Spectrometry, Anal. Chem. 1996, 68, 1924-1932. (doi: 10.1021/ac9509364)
Lazar, I.M.; Lee, M.L., CE-TOFMS for the Analysis of Paraquat and Diquat Herbicides, Proceedings of the 19th International Symposium on Capillary Chromatography and Electrophoresis, Huethig GmbH Heidelberg, 1997, 482-483.
Lazar, I.M.; Lee, M.L., Capillary Electrophoresis/Electrospray Ionization/Time-of-flight Mass Spectrometry, Proceedings of the 19th International Symposium on Capillary Chromatography and Electrophoresis, Huethig GmbH Heidelberg, 1997, 112-113.
Lazar, I.M.; Xin, B.; Lee, E.D., Lee, M.L., Design of a Capillary Electrophoresis-Electrospray Time-of-Flight Mass Spectrometer, Proceedings of the 18th International Symposium on Capillary Chromatography and Electrophoresis, Huethig GmbH Heidelberg, 1996, 149-152.
Lazar, I.M.; Lee, E.D., Lee, M.L., Optimization of a Corona Discharge Ion Source for Supercritical Fluid Chromatography Time-of-Flight Mass Spectrometry, Proceedings of the 17th International Symposium on Capillary Chromatography and Electrophoresis, Huethig GmbH Heidelberg, 1995, 522-523.
BOOKS
Iulia M. Lazar, Maria Kontoyianni, Alexandru C. Lazar, Eds., Proteomics for Drug Discovery Methods and Protocols, Methods in Molecular Biology, vol. 1647, Springer, New York, NY, 2017. (doi.org/10.1007/978-1-4939-7201-2; Print ISBN 978-1-4939-7200-5; On-line ISBN 978-1-4939-7201-2).
SUPPLEMENTS/OUTREACH/EDITORIAL ARTICLES
Lazar, I.M., “Preface” to Proteomics for Drug Discovery, book in the series of Methods in Molecular Biology, Iulia M. Lazar, Maria Kontoyianny, Alexandru C. Lazar, Eds., Springer, 2017.
Lazar, I.M., Karcini, A., “SKBR3/HER2+ Breast Cancer Cellular Response to Lapatinib and Ipatasertib Kinase Inhibitors,” ProteomeXchange Consortium via PRIDE partner repository, PXD051094 (2024).
Lazar, I.M.; Ahuja, S.A., “SKBR3/HER2+ Breast Cancer Cellular Response to Brain Cell-Secreted Factors,” ProteomeXchange Consortium via PRIDE partner repository, PXD046330 (2023).
Lazar, I.M.; Ahuja, S.A., “Anti-Inflammatory Cytokine Stimulation of HMC3 Cells: Proteome Dataset,” Mendeley Data (2023), DOI: 10.17632/fvhw2zwt5d.1. https://data.mendeley.com/datasets/fvhw2zwt5d.
Lazar, I.M.; Karcini, A., “Proteomic Analysis of Human SKBR3/HER2+ Breast Cancer Glycosylated Cell-surface Proteins,” ProteomeXchange Consortium via PRIDE partner repository, PXD028976 (2022). https://www.ebi.ac.uk/pride/archive/projects/PXD028976
Lazar, I.M.; Karcini, A., “Proteomic Analysis of Human SKBR3/HER2+ Breast Cancer Cell-surface Proteins by Using Amine Group Biotinylation,” ProteomeXchange Consortium via PRIDE partner repository, PXD028977 (2022). https://www.ebi.ac.uk/pride/archive/projects/PXD028977
Lazar, I.M.; Karcini, A., “Proteomic Analysis of Human SKBR3/HER2+ Breast Cancer Cell-surface Proteins by Tryptic Shaving,” ProteomeXchange Consortium via PRIDE partner repository, PXD028978 (2022). https://www.ebi.ac.uk/pride/archive/projects/PXD028978
Lazar, I.M.; Ahuja, S.A., “Proteomic Analysis of Human Microglia Cells (HMC3) Stimulated With Anti-inflammatory Cytokines Using Serum-deprived Culture Conditions,” ProteomeXchange Consortium via PRIDE partner repository, PXD023163 (2020). http://www.ebi.ac.uk/pride/archive/projects/PXD023163
Lazar, I.M.; Ahuja, S.A., “Proteomic Analysis of Human Microglia Cells (HMC3) Stimulated With Anti-inflammatory Cytokines Using Serum-enriched Culture Conditions,” ProteomeXchange Consortium via PRIDE partner repository, PXD023166 (2020). http://www.ebi.ac.uk/pride/archive/projects/PXD023166
Lazar, I.M.; Karcini, A.; Ahuja, S.A., “Proteomic Dataset for Exploring Somatic Mutations,” ProteomeXchange Consortium via PRIDE partner repository, PXD014458 (2019). http://www.ebi.ac.uk/pride/archive/projects/PXD014458
Lazar, I.M.; Deng, J.; Ahuja, S. A.; Karcini, A. “Short Enzymatic Reactions in Proteomics Studies,” ProteomeXchange Consortium via PRIDE partner repository with dataset indetifier PXD010306 (2018). https://www.ebi.ac.uk/pride/archive/projects/PXD010306
Lazar, I.M.; Sarvaiya, H.A., “Insulin Stimulated MCF7 Breast Cancer Cells,” ProteomeXchange Consortium via PRIDE partner repository with the dataset identifier PXD004051 (2016). https://www.ebi.ac.uk/pride/archive/projects/PXD004051
Lazar, I.M., “Microfluidic Devices and Methods Facilitating High-Throughput, On-Chip Detection of Separation Techniques.” Disclosure (06-057) Sep. 2005; US Utility Aug. 2006; PCT Aug. 2007, Issued US 7,744,762 B2, Jun 29, 2010.
Lazar, I.M.; Karger, B.L., “Microchip Integrated Multichannel Electroosmotic Pumping System.” Provisional application US292780P, May 22, 2001; Patent application, May 22, 2002, US20040208751; US 20,040,208,751 A1, Oct. 21, 2004.